Tokaramide A, a new cathepsin B inhibitor from the marine sponge Theonella aff. mirabilis

N Fusetani; M Fujita; Y Nakao; S Matsunaga; R W Van Soest

doi:10.1016/s0960-894x(99)00618-6

Tokaramide A, a new cathepsin B inhibitor from the marine sponge Theonella aff. mirabilis

Bioorg Med Chem Lett. 1999 Dec 20;9(24):3397-402. doi: 10.1016/s0960-894x(99)00618-6.

Authors

N Fusetani¹, M Fujita, Y Nakao, S Matsunaga, R W Van Soest

Affiliation

¹ Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan.

PMID: 10617079
DOI: 10.1016/s0960-894x(99)00618-6

Abstract

A new cathepsin B inhibitor, tokaramide A (1) has been isolated from the marine sponge Theonella aff. mirabilis. Its structure was determined by spectroscopic and chemical methods. Tokaramide A inhibits cathepsin B with an IC50 value of 29.0 ng/mL.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cathepsin B / antagonists & inhibitors*
Chromatography, High Pressure Liquid
Cysteine Proteinase Inhibitors / chemistry
Cysteine Proteinase Inhibitors / isolation & purification*
Cysteine Proteinase Inhibitors / pharmacology
Magnetic Resonance Spectroscopy
Oligopeptides / chemistry
Oligopeptides / isolation & purification*
Oligopeptides / pharmacology
Porifera / chemistry*
Spectrometry, Mass, Fast Atom Bombardment
Stereoisomerism

Substances

Cysteine Proteinase Inhibitors
Oligopeptides
tokaramide A
Cathepsin B